Prof. apt. Marlia Singgih Wibowo, Ph.D.

Professor

1. Fermentasi antibiotik Sefalosporin dan Pemuliaan galur Cephalosporium acremonium dengan cara mutasi sinar uv
2. Produksi antikolesterol (Lovastatin) dari Aspergillus terreus dan Monascus purpureus dengan cara fermentasi
3. Pemuliaan galur Aspergillus terreus melalui fusi protoplast
4. Studi Transformasi genetik Monascus purpureus.
5. Studi protein spesifik dari Mycobacterium tuberculosis untuk mencari kandidat vaksin baru untuk penyakit  TBC
6. Fermentasi dan modifikasi pigmen karotenoid dari jamur oncom Neurospora sp. untuk pewarna obat, makanan dan kosmetika

1. Saptarini, N.M., Wibowo, M.S., Gusdinar, T., “Correlation study of serum calcium levels and serum cartilage oligomeric matrix protein levels in rheumatoid arthritis patients in Bandung, Indonesia”, Asian Journal of Pharmaceutical and Clinical Research 2017
2. Saptarini, N.M., Pratiwi, D.E., Febrina, E., Wibowo, M.S., Gusdinar, T., “Correlation study of disease activity score and serum cartilage oligomeric matrix proteinlevels of rheumatoid arthritis patients in Bandung, Indonesia”, Asian Journal of Pharmaceutical and Clinical Research 2017
3. Zuhrotun, A., Suganda, A.G., Wirasutisna, K.R., Wibowo, M.S., “Isolation of bioactive compound of Michelia champaca L. bark and its activity test using mechanism-based yeast bioassay”, Asian Journal of Pharmaceutical and Clinical Research 2016
4. Zuhrotun, A., Suganda, A.G., Wirasutisna, K.R., Wibowo, M.S., “Anticancer screening of selected Apocynaceae, Simaroubaceae and Magnoliaceae of Indonesian plants using mechanism-based yeast bioassay ”, International Journal of Pharmaceutical Sciences Review and Research 2015
5. Saptarini, N.M., Wibowo, M.S., Gusdinar, T., “Correlation study of age, disease duration, and erythrocyte sedimentation rate among the Indonesian rheumatoid arthritis patients”, International Journal of Pharmacy and Pharmaceutical Sciences 2015
6. Ruslin , Kartasasmita, R.E., Wibowo, M.S., Ibrahim, S., 2014, “Pharmacokinetic properties and binding affinity prediction of leonurine and its derivatives design on phospodiesterease-5”, International Journal of Research in Pharmaceutical Sciences, Volume 5, Issue 1, 2014, Pages 7-13
7. Sri Priatni, Sophi Damayanti, Vienna Saraswaty, Diah Ratnaningrum, Marlia Singgih, 2014, “The Utilization of Solid Substrates on Monascus Fermentation for Anticholesterol Agent Production Procedia  chemistry 9 (2014) 34-39
8. Marlia Singgih, Vienna Saraswaty, Diah Ratnaningrum, Sri Priatni, Sophi Damayanti, 2014, “The Influence of Temperature and Ethanol Concentration in Monacolin K Extraction from Monascus Fermented Rice”, Procedia Chemistry, 9 (2014) 242 – 247
9. Singgih, M., Damayanti, S., Pandjaitan, N., 2014, “Antimicrobial activity of standardized piper betel extract and its mouthwash preparation (2014) International Journal of Pharmacy and Pharmaceutical Sciences, 6 (7), pp. 243-246.
10. Diastuti, H., Maolana Syah, Y., Dewi Juliawaty, L., Singgih, M., 2014, “Antibacterial activity of germacrane type sesquiterpenes from Curcuma heyneana rhizomes”,  Indonesian Journal of Chemistry, 14 (1), pp. 32-36.
11. Ruslan, K., Rukayadi, Y., Wahyuningsih, R., Singgih, M., Elfahmi, “Antimicrobial and cytotoxic activities of Jatropha curcas Linn. seedcake from biofuel production”, 2012,  Journal of Pure and Applied Microbiology, 6 (2), pp. 645-651.
12. Sri Priatni, Marlia Singgih, LBS Kardono, Tutus Gusdinar , “Fatty Acid Methyl Ester from Neurospora Intermedia N-1 Isolated from Indonesian Red Peanut Cake”, 2010,  Pakistan Journal of Biological Sciences, 13 (15): 731-737, 2010, ISSN 1028-8880
13. Sri Priatni, Marlia Singgih, LBS Kardono, Tutus Gusdinar, “Molecular identification of Neurospora sp N-1 isolated from Indonesian red peanut cake”, 2010, Journal of Pure & Applied Microbiology vol. 04 No. 02 2010
14. Putranti Adirestuti, Marlia Singgih Wibowo, Aska Firmansyah, Adhisty Nurpertamasari, “Bakteri Luminesens, Mikrobiota Laut yang Potensial sebagai Produsen Enzim Penting bagi Pengembangan Bidang Medis”, 2008,  Aristoteles vol.5,no.2, April 2008, ISSN.1693-5543, p.48-54.
15. Tiana Milanda, Marlia Singgih Wibowo, Tutus Gusdinar, Haryanto Dhanutirto, “Mutation and Characterization of an Albino Mutant of Monascus spp. Isolated from The Cikapundung River, Bandung, 2007, Microbiology Indonesia, vol.1,no.1, April 2007, ISSN 1978-3477,Accrediation A no.39/Dikti/Kep./2004 to Nov.2007, p.19-22.
16. Marlia Singgih Wibowo, Haryanto Dh., Diana Dewi, “Peningkatan Produksi Lovastatin oleh Kapang Aspergillus terreus melalui Fusi Protoplas”, 2005, Acta Pharmaceutica Indonesia,vol.XXX, no.1,  ISSN 0216-616X.

1. Tutus Gusdinar, Marlia Singgih, Tiana Milanda, Haryanto Dhanutirto, Determination and Genetic Variation Analysis of Wild-type and Albino’s Mutant of Monasus spp. by  Random Amplification of Polymorphic DNA (RAPD) Method, The 2nd AASP Symposium and 2nd APEM Conference, Bangkok, Thailand, 14-17 November, 2005.
2. Marlia Singgih, Tutus Gusdinar, Dudi Hardianto, Transformation of PULJL43 Plasmid into Monascus purpureus Albino Mutant, 5th Asia Pacific Biotechnology Congress and 35th Philippine Society for Microbiology Inc.(PSM) Annual Convention, Tagbilaran-Bohol, the Philippines, 10-13 May 2006
3. Marlia Singgih Wibowo, Winarni, Aktivitas Antifungi Yogurt terhadap Candida albicans (CAST) BERKHOUT yang Diisolasi dari Apusan Vagina Wanita, Kongres dan Seminar Ilmiah ISFI ke 15, Jakarta, 18-19 Juni 2007.
4. Dewi Astriyani, Marlia Singgih, Embit kartadarma, Penentuan  Angka Escherichia coli  dengan Metode Spektrofluorometri menggunakan Substrat metilumbeliferil-D-Glukuronida, Kongres dan Seminar Ilmiah ISFI ke 15, Jakarta, 18-19 Juni 2007.
5. Yustine Ardina, Sasanti Tarini Daryanto, Irda Fidrianny, Marlia Singgih, Development of Antiacne Gel Formulation and Minimum Inhibitory Concentration Determination from Papaya (Carica papaya Linn.) Leaves Extract, International Seminar on Pharmaceutics, School of Pharmacy ITB, Bandung, Indonesia, 31 Oktober-1 November, 2007. Poster session no.P-146.
6. Marlia Singgih Wibowo, Maria Immaculata Iwo, Lydia Metasari, Effects of Centella asiatica (L.) URB Extracts on Nitrogen Oxide Radical Production by Peritoneal Macrophage from Female Swiss-Webster Mice, International Seminar on Pharmaceutics, School of Pharmacy ITB, Bandung, Indonesia, 31 Oktober-1 November, 2007.
7. Sri Priatni, Marlia Singgih, LBS Kardono, Tutus Gusdinar, Produksi Pigmen Karotenoid dari Kapang Oncom Merah (Neurospora spp.) Melalui Pemanfaatan Ampas Sisa Produksi, Presentasi oral pada Seminar Nasional Pigmen 2008, Universitas Kristen Satya Wacana, Salatiga, Indonesia, 5 September 2008.
8. Marlia Singgih Wibowo, R.E. Kartasasmita, S.F.Widya Nala Utami, Penetapan Kualitas Mikrobiologi Susu Kedelai Kental Manis, Seminar Nasional dan Kongres PATPI (Perhimpunan Ahli Teknologi Pangan Indonesia), Palembang, Indonesia, 14-16 Oktober 2008.
9. Marlia Singgih Wibowo, Irda Fidrianny, Novrita Lestia Utami, Antimicrobial Activity of Ethanol Extract of Indonesian Tea Leaves (Camellia sinensis L.) against Streptococcus mutans Isolated from Dental Caries Patients, Poster Presentation at 11th Government Food Analysts Conference, National Measurement Institute, Melbourne, Australia, 22-24 February 2009.
10. Marlia Singgih Wibowo, Tutus Gusdinar, Triyani Sumiati, Transformation of pSTA14 Plasmid into Monascus purpureus Mutant Protoplast, Oral presentation at Bandung International Conference on Medicinal Chemistry, School of Pharmacy ITB, Bandung, 6-8 August 2009.
11. Marlia Singgih Wibowo, Comprehensive Study of Indonesian Red Rice Angkak (Monascus purpureus) to Utilize its Secondary Metabolites in Pharmacy, Key-note presentation at  2nd International Seminar on Advanced Molecular Biology,  Padang, Indonesia, 18 August 2009
12. Sri Priatni, Marlia Singgih Wibowo, Tutus Gusdinar, LB Kardono, Molecular Identification of Neurospora sp N-1 isolated from Indonesian Red peanut-cake (oncom merah), Poster presentation at 2nd International Seminar on Advanced Molecular Biology,  Padang, Indonesia, 18 August 2009
13. Sri Priatni, Leenawaty S., Marlia Singgih, LBS Kardono, Tutus Gusdinar, Identification  of carotenoids in Neurospora intermedia N-1 isolated from   Indonesian fermented peanut cake, Proceedings of NP-SEA: from basic science to application, Malang, East Java, Indonesia, March 20-21st 2010, ISBN 978-602-97123-0-8
14. Sasanti TD, Marlia Singgih, Irda F, Rista A., Formulation and Antibacterial Activity Test from Ethyl Acetate Fraction of Green Tea [ Camellia sinensis (L) O.K] to Propionibacterium acnes, Poster presentation in International Seminar on Cosmetics, Bandung Indonesia, November 26-27, 2010.
15. Marlia Singgih Wibowo, Amir Musadad, Tedjo Narko, Pengaruh Bacillus firmus terhadap produksi monakolin dan  pigmen merah Monascus purpureus secara fermentasi cair, Presentasi oral pada Kongres Ilmiah IAI (Ikatan Apoteker Indonesia), 28-30 Oktober, 2011, Manado, Indonesia.

• Marlia Singgih Wibowo, Debbie S.Retnoningrum, Dewi Astriyani, Valen Yurani, Pharmaceutical Microbiology Laboratory Guidebook for International Class, (editor: Lucy D.N.Sasongko and Kusnandar Anggadiredja), School of Phamacy ITB, Indonesia, Penerbit ITB, 2007, ISBN 978-979-1344-12-8.

1. Hibah Pasca (Peneliti anggota), DepDiknas, 2004-2006, Pencarian Sistem Informasi Genetik yang efisien untuk kapang Monascus purpureus sebagai penelitian awal rekayasa genetik untuk menghilangkan metabolit toksik sitrinin.
2. RUTI III (Peneliti Utama), Kementrian. Ristek RI, 2004-2006, Development of New Vaccines and Diagnostics for Tuberculosis through Proteomics.
3. Program Penelitian Fundamental (Peneliti Utama), DepDiknas RI, 2006, Transformasi Gen Resistensi Higromisin B ke Genom Kapang Monascus purpureus Mutan Albino Melalui mediasi Agrobacterium tumefaciens
4. Program Penelitian KK ITB (Peneliti utama), Modifikasi Struktur Sitrinin untuk Memperoleh Senyawa Antimikroba dengan Toksisitas Rendah, 2008-2009,
5. Hibah Kompetitif Strategis Nasional Batch II (Peneliti Utama) DIKTI, 2009-2010, Pengembangan Pigmen Karotenoid dari Jamur Oncom Merah (Neurospora sp.) sebagai Pewarna Alami Bahan Obat dan Makanan

1. Ko-promotor untuk Tiana Milanda (Promotor : Prof. Dr. Haryanto Dhanutirto), dengan judul Disertasi : Transformasi Genetik Monascus purpureus HD-001 (selesai 2007)
2. Ko-promotor untuk Dewi Astriyani (Promotor : Prof.Dr. Slamet Ibrahim), dengan judul Disertasi : Modifikasi metabolit sekunder Monascus purpureus melalui manipulasi jalur biosintesis sitrinin (mulai 2006, masih berlangsung)
3. Ko-promotor untuk Sri Priatni (Promotor : Dr. Tutus Gusdinar), dengan judul Disertasi : Modifikasi pigmen beta karoten hasil fermentasi kapang oncom Neurospora sp. (mulai 2008, selesai 2011)