Debbie Soefie Retnoningrum, Dr., Apt.

KK Farmasetika
Associate Professor

Email : debbie at fa.itb.ac.id, retnoningrum at indo.net.id
Telepon : +62 (22) 250 4852

Bidang Keahlian

  1. Streptococcus pyogenes: A study on several virulence factors (M protein, Laminin-binding protein, Fibronectin-binding protein, streptokinase) and virulence activator, MgA, development of virulence factor-based-vaccine, molecular detection and novel drugs against streptococcal infection.
  2. Hepatitis B virus: A study on wild type and vaccine escape mutants of HBsAg at molecular level, development of vaccine escape mutants HBsAg-based vaccine and detection for hepatitis B infection.

 

Publikasi di Jurnal

  1. Debbie S. Retnoningrum, Ratih A. Ningrum, Yohanes N. Kurniawan, Ana Indrayati and Heni Rachmawati, Construction of Synthetic Open Reading Frame Encoding Human Interferon Alpha 2b for High Expression in Escherichia Coli 8 and Characterization of Its Gene Product, Journal of Biotechnology 145, 2010, 193-198.
  2. Roga F. Kembaren, adam R. Ganjara, Valentina Yurina, and Debbie S. Retnoningrum, The role of the First 14 Amino Acids of Mature M1 Protein of Streptococcus pyogenes on Fibronectin-Binding Activity and Dimer Formation, Mikrobiologi Indonesia, 4(1): 2010.
  3. Debbie S. Retnoningrum, Ratih A. Ningrum, Yohanes N. Kurniawan, Ana Indrayati and Heni Rachmawati, “CONSTRUCTION OF SYNTHETIC OPEN READING FRAME ENCODING HUMAN INTERFERON ALPHA 2b FOR HIGH EXPRESSION IN ESCHERICHIA COLI 8 AND CHARACTERIZATION OF ITS GENE PRODUCT”, Journal of Biotechnology 2009, in press
  4. Retnoningrum, DS.2006, “Molecular Mechanisms of Virulence Mediated by Surface-Associated Proteins in Streptococcus pyogenes: a Short Review”, Jurnal Mikrobiologi Indonesia, 11(2): 51-56.
  5. Retnoningrum, DS.2005, “Virulence factors of Streptococcus pyogenes and their benefits in pharmacy field”, Towards Bright and Brilliant Indonesian, LIPI Press, ISBN: 979-3673-60-5, 97-116 (in Indonesian).
  6. Retnoningrum, D. S., D. Natalia, and M. F. Tuite, 2000, “Construction and Characterization of mutant sup45 allelles leading to defects translation termination in Saccharomyces cerevisiae”, Indonesian Journal of Biotechnology, Special Issues, June, 2000
  7. Iwo, M.I., Soemardji, A.A., Retnoningrum, D.S., and Uu M., 2000, “Immunostimulating effect of Pule (Alstonia scholaris L. R. Br., Apocynaceae”, Clin. Hemorheol. Microcirc., 23(2,3,4): 177- 183.
  8. Johansson P. J., Malone C. C., Williams R.C., Retnoningrum D. S., Cleary P.P.,1994“Streptococcus pyogenes type M12 protein shows selective binding to some human immunoglobulin G3 myeloma proteins”. Infect Immun. 62(8):3559-63.
  9. Retnoningrum D. S. and Cleary P. P., 1994, “M12 protein from Streptococcus pyogenes is a receptor for immunoglobulin G3 and human albumin”. Infect Immun. 1994 Jun;62(6):2387-94.
  10. Cleary P, and Retnoningrum D. “Group A streptococcal immunoglobulin-binding proteins: adhesins, molecular mimicry or sensory proteins?”, Trends Microbiol.,1994, 2(4): 131-6.
  11. Retnoningrum D. S., Podbielski A., and Cleary P. P. “Type M12 protein fromStreptococcus pyogenes is a receptor for IgG3″. J Immunol. 1993 Mar 15;150(6):2332-40.
  12. Susilo, R.A., Sumirtapura, Y.C., Rachmawati, H., Darijanto, S.T., Retnoningrum, D.S., Kardono, L.B.S., 2012, “Over production of human recombinant interferon a-2b: Scaling up process”, Journal of Applied Sciences, 12 (15), pp. 1613-1617.
  13. Pramesti, H.T., Suciati, T., Indrayati, A., Asjarie, S., Retnoningrum, D.S., 2012, “Recombinant human Bone Morphogenetic Protein-2: Optimization of overproduction, solubilization, renaturation and its characterization”, Biotechnology, 11 (3), pp. 133-143.
  14. Retnoningrum, D.S., Pramesti, H.T., Santika, P.Y., Valerius, O., Asjarie, S., Suciati, T., 2012, “Codon optimization for high level expression of human bone morphogenetic protein – 2 in Escherichia coli”,Protein Expression and Purification, 84 (2), pp. 188-194.
  15. Rachmawati, H., Febrina, P.L., Ningrum, R.A., Retnoningrum, D.S., 2012, “The influence of polyethylene glycol structure on the conjugation of recombinant human interferon a2b overproduced using synthetic gene in E.coli”, International Journal of Research in Pharmaceutical Sciences, 3 (2), pp. 228-233.
  16. Purkan, Ihsanawati, Syah, Y.M., Retnoningrum, D.S., Noer, A.S., Shigeoka, S., Natalia, D., 2012, “Novel mutations in katG gene of a clinical isolate of isoniazid-resistant Mycobacterium tuberculosis”, Biologia, 67 (1), pp. 41-47.
  17. Vidilaseris, K., Hidayat, K., Retnoningrum, D.S., Nurachman, Z., Noer, A.S., Natalia, D., 2009, “Biochemical characterization of a raw starch degrading a-amylase from the Indonesian marine bacterium bacillus sp. ALSHL3”, Biologia, 64 (6), pp. 1047-1052.
  18. Rachmawati, H., Merika, A., Ningrum, R.A., Anggadiredja, K., Retnoningrum, D.S., 2013, “Evaluation of adverse effects of mutein forms of recombinant human interferon alpha-2b in female Swiss Webster mice”, BioMed Research International, 2013, art. no. 943687

 

Publikasi di Konferensi

  1. Catur Riani, Akhmad Muchlisin, Casilawaty, Debbie Sofie Retnoningrum, Overexpression Of Cyclodextrin Gl Ycosyltransferase Synthetic Gene From Bacillus sp A2-5a in Escherichia Coli, The symposium: Networking and Technology Transfer, Bangkok, Thailand, from 7 -12 June 2010.
  2. Catur Riani, Akhmad Muchlisin, Casilawaty, Debbie Sofie Retnoningrum, Cyclodextrin Gl Ycosyltransferase Synthetic Gene of Bacillus sp A2-5a: Overexpression In Escherichia Coli And Characterization Of The Product, Conference of Industrial Enzyme and Biotechnology 2010 (CIEB 2010), di BPPTSerpong, 3 Agustus 2010, dengan tema : Enzyme Technology for Eco-Friendly Industry.
  3. Catur Riani, Usma Nurul WB, Mieke Hemiawati Satari, Debbie S. Retnoningrum, Biofilm of Oral Bacteria: A Preliminary Study, Gruber-Soedigdo Lecture (GSL) ke III, KK Biokimia Prodi Kimia – RS. Santosa, Bandung, 27 Juli 2010.
  4. Priani, S.E., Artarini A. A., Ellyasheva R., and Retnoningrum, D.S., “Cloning Of DNA Encoding For Putative Laminin Binding Domain From Type M12 Streptococcus pyogenes“, International Seminar On Pharmaceutics, School of Pharmacy ITB, 31 Okt – 01 Nov, 2007
  5. Debbie Sofie Retnoningrum, Sri Wahyuningsih, Catur Riani, Mariani Pujiastuti, Reny Ellyasheva and Maria Immaculata Iwo, “Recombinant Laminin-Binding Protein As A Vaccine Candidate Against Infection Of Streptococcus pyogenes“, International Seminar On Pharmaceutics, School of Pharmacy ITB, 31 Okt – 01 Nov,2007
  6. Kurniawan YN, Retnoningrum DS, Indrayati A., Rachmawati H, “The Construction And Cloning Of Synthetic Interferon Alpha-2b (Ifn?2b) Coding Sequence InEscherichia coli Jm 109″, International Seminar On Pharmaceutics, School of Pharmacy ITB, 31 Okt – 01 Nov, 2007
  7. Fuad AM, Gusdinar T, Retnoningrum DS, Natalia D, “Recombinant Human-Erythropoietin (Hepo) Expression In Pichia pastoris Using An Epo-Synthetic Gene Having Yeast Codon”, International Seminar On Pharmaceutics, School of Pharmacy ITB, 31 Okt – 01 Nov, 2007
  8. “Overview of Microarray Technology and DNA Chips: Principle and Applications”, Asean Conference in Medical Laboratory Technology, Jakarta, May 23, 2006 (in English).
  9. “Molecular Approach for Drug Discovery from marine microorganisms”, International Seminar and Workshop: Marine Biodiversity and their Potential for Developing Bio-pharmaceutical Industry in Indonesia, International Seminar and Workshop: Marine Biodiversity and their Potential for Developing Bio-pharmaceutical Industry in Indonesia, May 17-18, Jakarta, 2006 (in English).
  10. Retnoningrum, D.S., 2002, “Regulation of virulence factors of Streptococcus pyogenes and its role in the discovery of novel antipathogenic compounds”, Pertemuan Ilmiah Tahunan, Perhimpunan Mikrobiologi Indonesia (Permi), Medan, 1-2 Oktober 2002
  11. Retnoningrum, D.S., 2002, “Molecular biology of Streptococcus pyogenes and its role in the discovery of novel antipathogenic substances”, Seminar MIPA III, Bandung, 21-22 Oktober 2002
  12. Retnoningrum, D.S., 2002, “Molecular pathogenesis of Streptococcus pyogenesand its role in the discovery of novel antipathogenic compounds and in the development of vaccines”, Seminar Pemaparan Hasil Penelitian Hibah Bersaing, Jakarta, 9 Agustus 2002
  13. Retnoningrum, D. S., 2002, “Directed Strategy Towards Discovery of Novel Antipathogenic Substances and Their Clinical Use”, Symposium: The Advanced Therapy for Year 2003, The Update on Drugs and Methods in Medicine-2, Bandung Medical Forum, PERALMUNI Bandung Branch, 29 September 2002
  14. D.S. Retnoningrum, E. Purwantini, E. Widodo, and K. Senjarini, 2002, “Streptococcal Mga49 contains two different binding domains for emm and mga activator sites”, The XV Lancefield International Symposium on Streptococci and Streptococcal Diseases, Goa, India, 6-11 October 2002, Abstract P 3.29.
  15. R. Ellyasheva, R. F. Kembaren, D. Natalia and D. S. Retnoningrum, 2002, “Cloning of DNA encoding ABS fragment of M1 protein of Streptococcus pyogenes inSaccharomyces cerevisiae“, Seminar Nasional Hasil Penelitian Farmasi, Bandung, Indonesia, 25 September 2002
  16. R.F. Kembaren, E. Purwantini, and D.S. Retnoningrum, 2002, “Substitution of Arginine 123 with Asparagine in Mga protein of Streptococcus pyogenes“, Seminar Nasional Hasil Penelitian Farmasi, Bandung, Indonesia, 25 September 2002
  17. R. F. Kembaren, M. Suhendar, and D. S. Retnoningrum, 2002, “Overproduction and Characterization of Recombinant ABC fragment of M1 Protein ofStreptococcus pyogenes“, Seminar MIPA III, Bandung, 21-22 Oktober 2002
  18. R. F. Kembaren, Y. Sribudiani, A. Suharto, and D. S. Retnoningrum, 2002, “Cloning of DNA encoding for Fibronectin -binding domain of M1 Protein of Streptococcus pyogenes“, Seminar Konsorsium Bioteknologi Indonesia, Bandung, Indonesia, 11 October 2002
  19. A. Braun-Kiewnick, D. S. Retnoningrum, A. Podbielski, and B. Kreikemeyer, 2001, “Isolation and characterization of quorum-sensing (QS) related substances regulating virulence gene expression in Streptococcus pyogenes“, Streptococcal genetics meeting, October 2001, Aachen.
  20. Retnoningrum, D. S., 2000, “Design of molecular biology to overcome infectious disease: Streptococcus pyogenes as a model”, Association of Allergy and Immunology, Allergy Paradigm, Immunology for the 21st century, Bandung, 11-13 February, 2000
  21. Retnoningrum, D. S., 2000, “The role of molecular analysis for detection of intracellular pathogens, Association of Allergy and Immunology”, Scientific symposium on medicine, The Update on New Drugs and Methods in Medicine, Bandung, 6-8 October 2000
  22. Kreikemeyer, B., D. S. Retnoningrum, and A. Podbielski, 2000, “Bacterial Signaling Peptides and Host Factors are involved in regulation of virulence factor gene expressions in Group A Streptococci (GAS)”, American Society for Microbiology, 100th General Meeting, Los Angeles Convention Center, Los Angeles, California, 21-25 May 2000, Abstract B-260.
  23. Kreikemeyer, B., D. S. Retnoningrum, and A. Podbielski, 2000, “Regulation of virulence factor expression in Group A Streptococci (GAS) by bacterial signaling peptides”, Microbiology 2000: Health-Ecology-Biotechnology, 23 February 2000
  24. Warganegara, E., I. Supardi, I. Supandiman, and D. S. Retnoningrum, 2000, “Nucleotide sequence changes of -lactamase gene due to in vitro sub-inhibition exposure of a mixture of amoxiciline-clavulanate of sensitive clinical isolates of Escherichia coli”, Association of Indonesian Clinical Microbiology, IV National Congress, Semarang, Indonesia, 23 – 25 March 2000
  25. Retnoningrum, D. S., 2000, “Mga protein as a molecular target for screening bioactive compounds against Streptococcus pyogenes“, Association of Indonesia Clinical Chemistry, VIII National Congress, Jakarta, Indonesia, 26-28 October 2000, Abstract MB602.
  26. Iswari, I. I., I. Supardi, I. Supandiman, and D. S. Retnoningrum, 2000, “Detection and Sequencing of gene s encoding type II chloramphenicol acetyltransferase from clinical isolates of Salmonella typhi in West Java”, Indonesia, Association of Indonesia Clinical Chemistry, VIII National Congress, Jakarta, Indonesia, 26-28 October 2000, Abstract P4.
  27. Retnoningrum, D. S., E. Warganegara, I. Supandiman, and I. Supardi, 1999, “Partial nucleotide sequences of -lactamase genes from several Indonesian Escherichia coli isolates”, 2nd HUGO Pacific Meeting, Genome Diversity in Asia Pacific, Sanur, Indonesia, 24-26 March 1999

 

Bantuan Penelitian

  1. Identifikasi Mutasi Gen Polimerase Virus hepatitis B dari Penderita di Beberapa Kota di Pulau Jawa, Hibah Pekerti batch V, principle investigator from ITB side, (Debbie S. Retnoningrum and Erna Giri Rachman), in collaboration with University of Garut, 2007-2008.
  2. Overexpression of Gene encoding for Chitinase from acidiphilic bacteria from Rawa Inderalaya, Hibah Pekerti batch IV, principle investigator from ITB side, 2006-2007.
  3. Use of lectin for purification of capsul of Streptococcus pneumoniae, Hibah Bersaing, team member, 2006-2007.
  4. Karakterisasi Dan Kloning Gen Pengkode Vp28 White Spot Syndrome Virus (Wssv) Isolat Indonesia Sebagai Kandidat Vaksin Rekombinan Untuk Pengendalian Penyakit Bintik Putih Pada Udang Windu (Penaeus monodon), Hibah pekerti batch IV, principle investigator from ITB side, in collaboration with Faculty of Fischery, University of Hasanuddin, 2006-2007.
  5. Construction of mutant streptokinase with longer in vitro half-life, Riset Unggulan Terpadu XII, principal investigator (Debbie S. Retnoningrum, Reny Elyasheva, Maria Immaculata), 2005-2006.
  6. Construction of vaccine escape mutant of G145R HBsAg of Hepatitis B virus, Hibah Bersaing XIII, team member (Sri Anendya Lestari, Roga F. Kembaren, Debbie S. Retnoningrum), 2005-2006.
  7. Construction of vaccine escape mutant of M133T HBsAg of Hepatitis B virus, Indonesia Toray Science Foundation, team member (Sri Anendya Lestari, Debbie S. Retnoningrum), 2005.
  8. Overproduction of recombinant human erithropoeitin, Riset Unggulan Teradu XII, team member (Adi Santoso, Asrul M. Fuad, Debbie S. Retnoningrum), 2005-2007.
  9. Molecular characterization of meticilline-resistant Staphylococcus aureus, Hibah pekerti batch III, Principle investigator from ITB side, (Debbie S. Retnoningrumand Maelita R Moeis), in collaboration with Faculty of Medicine, University of Udayana, 2005.
  10. Laminin-binding protein as universal vaccine against streptococcal infection, Hibah Bersaing XII, team member (Catur Riani, Roga F. Kembaren, Debbie S. Retnoningrum), 2004-2005.
  11. Screening of antipathogenic substances against streptococcal infection from marine bacteria isolated in Indonesia, Indonesia Toray Science Foundation, team member (Roga F. Kembaren, Debbie S. Retnoningrum), 2004.
  12. Isolation of specific antigen of Mycobacterium tuberculosis reactive against serum from active TB patients, Hibah Pekerti batch II, Principle investigator from ITB side (Debbie S. Retnoningrum and Sri Anendya Lestari), in collaboration with Faculty of Medicine, University of Hasanuddin, 2004-2005.
  13. Molecular study of rifampicin and INH resistance of Mycobacterium tuberculosisisolated from Makassar, team member (Fatmawati Badaruddin, Asaad Maidin,Debbie S. Retnoningrum), 2003-2004.
  14. Molecular characterization of pyrazinamide resistance of Mycobacterium tuberculosis isolated from Makassar, Hibah Pekerti batch I, Principle investigator from ITB side (Debbie S. Retnoningrum and Roga F. Kembaren), in collaboration with Faculty of Medicine, University of Hasanuddin, 2003-2004.
  15. Molecular characterization of Helix-turn-helix structure of Mga, a streptococcal activator for its binding to activator binding site, Riset Unggulan Terpadu IX, team member, Catur Riani, Debbie S. Retnoningrum, Arlina Permatasari, 2002-2003.
  16. Molecular characterization of the interaction of Mga and its activator sites and its use as molecular target for antipathogenics agents againsts pathogenicStreptococcus pyogenes, Hibah Team, URGE, team member (Sarjono Kisman,Debbie S. Retnoningrum, Endang Purwantini), 1999 – 2001
  17. Biological functions of Streptococcus pyogenes M12 – human albumin interaction, RUT, principal investigator (Debbie S. Retnoningrum, Endang Purwantini, Sri Anendya Lestari), 2001 – 2003.
  18. Fibronectin-binding protein as a recombinant vaccine against Streptococcus pyogenes infection, Hibah Bersaing, team member, (Roga F. Kembaren, Debbie S. Retnoningrum, Dessy Natalia), 2001 – 2003.
  19. Cloning and screening of promoters of Streptococcus pyogenes responding to several environmental signals, Department of Microbiology, Virology, and Hygiene, University of Rostock, Rostock, Germany (funding from DFG, Germany), June – August 2001.
  20. Screening of compounds isolated from Indonesian microorganisms that interfere the interaction of Mga with mga activator sites and emm activator sites using gene fusion technology, IURC on Biotechnology – Department of Microbiology, Virology, and Hygiene, University of Rostock, Rostock, Germany, June – August 2001.
  21. Cloning and expression of scpA in Lactococcus lactis, visiting scientist program, Department of Microbiology, University of Minnesota, Minneapolis, USA, July – Agust 2000
  22. Mechanism of interaction between human albumin and M protein ofStreptococcus pyogenes, Penelitian Dasar, principal investigation (Debbie S. Retnoningrum, Tri Suciati and Maria Immaculata), 1999
  23. Isolation and characterization of secreted small molecule(s) regulating the expression of speB and sagA gene in Streptococcus pyogenes, Department of Medical Microbiology and Hygiene, University of Ulm, Ulm, Germany, Prof. Dr. dr. Andreas Podbielski, November – December 1999, funded by DAAD
  24. Gene expression in Saccharomyces cerevisiae, Research School of Biochemistry, University of Kent at Canterbury, UK, February – May 1997, Prof. Mike Tuite, funded by DFID, UK
  25. Development of colorimetric PCR for detection of pathogenic Streptococcus pyogenes, Young Academics Program, principal investigator, 1996 – 1998
  26. Isolation and identification of streptococcal proteins regulated by human serum albumin interaction in Streptococcus pyogenes, American Heart Association, principal investigator, 1993 – 1994
  27. Molecular characterization of M12 protein of Streptococcus pyogenes in relation to IgG3 and human albumin binding, doctoral student, 1988 – 1993
  28. Structural Investigation of an M1 protein with Fibronectin-binding Activity ofStreptococcus pyogenes with Human Fibronectin: From Basic Knowledge to Drug Development, International Collaborative Research Grant, School of Pharmacy (Debbie S. Retnoningrum, principal inverstigator, Erna Giri Rachman, Zeily Nurachman and Toto Subroto)

 

Pengalaman Mengajar

  1. Molecular biology, Faculty of Medicine, 2004 – present.
  2. Molecular biotechnology, elective course, 1998 – 2001.
  3. Molecular biology, compulsory course, double degree in Faculty of Medicine, 2000-2003.
  4. Molecular and Cellular Microbiology, compulsory course, 1999 – present
  5. Microbial biochemistry, compulsory course, 1999 – present
  6. Microbial genetics, compulsory course, 1999 – present
  7. Molecular immunology, compulsory course, 1999 – present
  8. Molecular pathogenesis, elective course, 1999 – present
  9. Recombinant DNA technology, elective course, 1999 – present
  10. Microbiology, compulsory course, 1998 – present
  11. Immunobiotechnology, elective course, 1998 – present
  12. Pharmaceutical veterinary, elective course, 1998 – present
  13. Molecular microbiology, compulsory course, in Indonesian, 1997 – 1998
  14. Bacterial molecular pathogenesis, compulsory course, in English, 1997
  15. Molecular techniques, laboratory, compulsory course, in Indonesian, 1997 – 1998
  16. Pharmaceutical biotechnology, elective course, 1994 – present
  17. Molecular Microbiology, compulsory course, 1994 – present.
  18. Grader, Virology, Winter quarter 1992, Prof. Dr. Peter Plagemann
  19. Teaching assistant, Microbiology for Medical Students, Spring quarter 1991, Prof. Dr. Patrick Schlievert.
  20. Teaching assistant, Medical Microbiology, Winter quarter 1990, Prof. Dr. P. Patrick Cleary.
  21. Grader, Physiology of Microorganisms, Winter quarter 1989, Prof. Dr. Palmer Rogers

 

Pengalaman terkait dalam penelitian dan pendidikan

  1. Member of selection board in the field of genetics and molecular biology, Risbin Iptekdok, 1995 – 1998; 2005 – present.
  2. Consultation for establishment of PCR-based method for control quality of vaccine production, PT Biofarma (2005 – present).
  3. Consultation for recombinant products for drugs and vaccines, Pusat Pengujian Obat dan Makanan Negara (2005 – present)
  4. Member of Selection Committee of Indonesia Toray Science Foundation (ITSF), 2004 – present.
  5. Consultation for recombinant protein control quality, PT Kalbe Farma (2003-2004)
  6. Member of selection board in the field of biotechnology, RUT, 1994 – 2000
  7. Reviewer of Indonesia Toray Science Foundation (ITSF) in the field of basic science, 2000 – 2004.
  8. Reviewer of Hibah Bersaing in the field of natural sciences, Final presentation, 2000 – 2004.
  9. Co supervisor and supervisor, doctoral and master degree students in the field of molecular biology of microorganisms, 1994 – present
  10. Reviewer of RUT in the field biotechnology, 1994 – 1998.
  11. Assessment for PCR-based laboratory (expert for Badan Standarisasi Nasional)

 

Keanggotaan Organisasi Ilmiah

  1. Indonesian Consortium of Biotechnology, secretary, 2002 – present.
  2. Indonesian Society of Microbiology, 2002 – present.
  3. Indonesian Society for Pharmacists, 1994 – present.
  4. American Society for Microbiology, 1992 – present.

 

Lain-lain

  1. (Award) The best presenter, Molecular characterization of the interaction of Mga and its activator sites and its use as molecular target for antipathogenics agents againsts pathogenic Streptococcus pyogenes, Seminar on Hibah Tim Penelitian Pascasarjana, Jakarta, DIKTI, 18 – 21 November 2001.
  2. (Award) Indonesia Science Toray Foundation award, 2001, Molecular pathogenesis of Streptococcus pyogenes and its role in the discovery of novel antipathogenic compounds and in the development of vaccines.
  3. Publikasi SCOPUS